Semaglutide
/ˌsɛməˈɡluːtaɪd/
A GLP-1 receptor agonist medication that mimics the glucagon-like peptide-1 hormone to control blood sugar by slowing down digestion and reducing appetite
Full explanation
Semaglutide is a prescription medication that works by mimicking GLP-1, a hormone your body naturally produces after eating. It's sold under some brand names such as Ozempic (weekly injection for type 2 diabetes), Wegovy (weekly injection for chronic weight management) and Rybelsus (daily pill for diabetes).
The medication works by stimulating insulin release when blood sugar is high, slowing how quickly food leaves the stomach and reducing appetite signals in the brain.
Most benefits reverse after stopping the medication, making lifestyle changes including improved nutrition and regular exercise essential for long-term health success.
Common misconceptions
"All three brands (Ozempic, Wegovy, Rybelsus) are interchangeable". While they contain the same active ingredient, they come in different doses and formulations; Ozempic and Rybelsus are FDA-approved for diabetes, Wegovy is approved for weight loss and they're not substitutable without medical guidance.
"The weight will stay off after you stop taking it". Most people regain two-thirds of their weight loss within a year of stopping semaglutide. The medication is designed for long-term use, similar to blood pressure or cholesterol medications.
"You can eat whatever you want while taking semaglutide". While it reduces appetite, the medication works best alongside healthy eating and exercise. Poor dietary choices can limit weight loss, worsen side effects and prevent long-term success.